Publications

A full list of publications can be found on Pubmed and Google Scholar.

Select publications include:

Clinical Informatics and Data Science:

Fohner AE, Greene JD, Lawson BL, Chen JH, Kipnis P, Escobar GJ, Liu VX. Assessing clinical heterogeneity in sepsis through treatment patterns and machine learning. J Am Med Inform Assoc. 2019 Jul 17;. doi: 10.1093/jamia/ocz106. [Epub ahead of print] PubMed PMID: 31314892.

Sridhar AR, Chen Amber ZH, Mayfield JJ, Fohner AE, Arvanitis P, Atkinson S, Braunschweig F, Chatterjee NA, Zamponi AF, Johnson G, Joshi SA, Lassen MCH, Poole JE, Rumer C, Skaarup KG, Biering-Sørensen T, Blomstrom-Lundqvist C, Linde CM, Maleckar MM, Boyle PM. Identifying risk of adverse outcomes in COVID-19 patients via artificial intelligence-powered analysis of 12-lead intake electrocardiogram. Cardiovasc Digit Health J. 2022 Apr;3(2):62-74. doi: 10.1016/j.cvdhj.2021.12.003. Epub 2021 Dec 31. PubMed PMID: 35005676; PubMed Central PMCID: PMC8719367.

Pharmacogenetics Discovery

Fohner AE, Ranatunga DK, Thai KK, Lawson BL, Risch N, Oni-Orisan A, Jelalian AT, Rettie AE, Liu VX, Schaefer CA. Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system. Pharmacogenet Genomics. 2019 Oct;29(8):192-199. doi: 10.1097/FPC.0000000000000383. PubMed PMID: 31461080.

Fohner AE, Robinson R, Yracheta J, Dillard DA, Schilling B, Khan B, Hopkins S, Boyer BB, Black J, Wiener H, Tiwari HK, Gordon A, Nickerson D, Tsai JM, Farin FM, Thornton TA, Rettie AE, Tummel KE. “Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX.” Pharmacogenet Genomics. 2015 Jul;25(7):343-53. PMID: 25946405

Fohner AE, Dalton R, Skagen K, Jackson K, Claw KG, Hopkins SE, Robinson R, Khan BA, Prasad B, Schuetz EG, Nickerson DA, Thornton TA, Dillard DA, Boyer BB, Thummel KE, Woodahl EL. Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities, targeting CYP3A4*1G allele function. Clin Transl Sci. 2021 Jul;14(4):1292-1302. doi: 10.1111/cts.12970. Epub 2021 Jan 27. PubMed PMID: 33503331; PubMed Central PMCID: PMC8301563.

Fohner A, Muzquiz LI, Austin MA, Gaedigk A, Gordon A, Thornton T, Rieder MJ, Pershouse MA, Putnam EA, Howlett K, Beatty P, Thummel KE, Woodahl EL. “Pharmacogenetics in American Indian populations: analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes.” Pharmacogenet Genomics. 2013 Aug;23(8):403-14. PMID: 23778323
 
 

Pharmacogenetics Synthesis and Clinical Recommendations

Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for ABCG2. Pharmacogenet Genomics. 2017 Nov;27(11):420-427. doi: 10.1097/FPC.0000000000000305. Review. PubMed PMID: 28858993; PubMed Central PMCID: PMC5788016.
 
Fohner AE, Sparreboom A, Altman RB, Klein TE. PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. Pharmacogenet Genomics. 2017 Apr;27(4):164-167. doi: 10.1097/FPC.0000000000000270. PubMed PMID: 28146011; PubMed Central PMCID: PMC5346035.
 
Fohner AE, Rettie AE, Thai KK, Ranatunga DK, Lawson BL, Liu VX, Schaefer CA. Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin-Induced Cutaneous Adverse Drug Reactions. Clin Transl Sci. 2020 Sep;13(5):1004-1009. doi: 10.1111/cts.12787. Epub 2020 Apr 18. PubMed PMID: 32216088; PubMed Central PMCID: PMC7485959.
 
Karnes JH, Rettie AE, Somogyi AA, Huddart R, Fohner AE, Formea CM, Ta Michael Lee M, Llerena A, Whirl-Carrillo M, Klein TE, Phillips EJ, Mintzer S, Gaedigk A, Caudle KE, Callaghan JT. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update. Clin Pharmacol Ther. 2021 Feb;109(2):302-309. doi: 10.1002/cpt.2008. Epub 2020 Sep 6. Review. PubMed PMID: 32779747; PubMed Central PMCID: PMC7831382.
 

Public Health Policy/Practice Guidelines:

Fohner, A.E.  N.A Garrison, M.A Austin, W Burke. “Carnitine Palmitoyltransferase 1A P479L and Infant Death: Policy Implications of Emerging Data.” Genetics in Medicine. In press.

Fohner AE, Wang Z, Yracheta J, O’Brien D, Hopkins SE, Black J, Philip J, Wiener HW, Tiwari HK, Stapleton PL, Tsai JM, Thornton TA, Boyer BB, Thummel KE. “Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup’ik Study Population from Southwestern Alaska.” J. Nutr. dos: 10.3945/jn115.223388.

Advancing Equity in Biomedical Research:

Fohner AE, Volk KG, Woodahl EL. Democratizing Precision Medicine Through Community Engagement. Clin Pharmacol Ther. 2019 Sep;106(3):488-490. doi: 10.1002/cpt.1508. Epub 2019 Jun 17. PubMed PMID: 31206610; PubMed Central PMCID: PMC6692197.

Xue, D., Blue, E. E., Conomos, M. P., & Fohner, A. E. (2024). The power of representation: Statistical analysis of diversity in US Alzheimer’s disease genetics data. Alzheimer’s & dementia (New York, N. Y.), 10(1), e12462. https://doi.org/10.1002/trc2.12462
 

Blood-based Biomarkers of Dementia, Alzheimer’s Disease, Cognitive Decline:

Short, M. I., Fohner, A. E., Skjellegrind, H. K., Beiser, A., Gonzales, M. M., Satizabal, C. L., Austin, T. R., Longstreth, W. T., Bis, J. C., Lopez, O., Hveem, K., Selbæk, G., Larson, M. G., Yang, Q., Aparicio, H. J., McGrath, E. R., Gerszten, R. E., DeCarli, C. S., Psaty, B. M., Vasan, R. S., … Seshadri, S. (2023). Proteome Network Analysis Identifies Potential Biomarkers for Brain Aging. Journal of Alzheimer’s disease : JAD, 96(4), 1767–1780. https://doi.org/10.3233/JAD-230145

Tin, A., Fohner, A. E., Yang, Q., Brody, J. A., Davies, G., Yao, J., Liu, D., Caro, I., Lindbohm, J. V., Duggan, M. R., Meirelles, O., Harris, S. E., Gudmundsdottir, V., Taylor, A. M., Henry, A., Beiser, A. S., Shojaie, A., Coors, A., Fitzpatrick, A. L., Langenberg, C., … Fornage, M. (2023). Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Communications biology, 6(1), 1117. https://doi.org/10.1038/s42003-023-05454-1

Fohner, A. E., Sitlani, C. M., Buzkova, P., Doyle, M. F., Liu, X., Bis, J. C., Fitzpatrick, A., Heckbert, S. R., Huber, S. A., Kuller, L., Longstreth, W. T., Feinstein, M. J., Freiberg, M., Olson, N. C., Seshadri, S., Lopez, O., Odden, M. C., Tracy, R. P., Psaty, B. M., Delaney, J. A., … Floyd, J. S. (2022). Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study. Journal of Alzheimer’s disease : JAD, 88(1), 7–15. https://doi.org/10.3233/JAD-220091

Fohner AE, Bartz TM, Tracy RP, Adams HHH, Bis JC, Djousse L, Satizabal CL, Lopez OL, Seshadri S, Mukamal KJ, Kuller LH, Psaty BM, Longstreth WT Jr. Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study. Neurology. 2022 Mar 1;98(9):e903-e911. doi: 10.1212/WNL.0000000000013229. Epub 2021 Dec 17. PubMed PMID: 34921102; PubMed Central PMCID: PMC8901174.

Education

Fohner, A. E., Whitson, H. E., & Aronson, L. (2023). What could go wrong? Reflections and roadmap for successfully engaging with public media. Journal of the American Geriatrics Society, 71(11), 3663–3667. https://doi.org/10.1111/jgs.18472

Xue, D., Hajat, A., Fohner, A.E. (2024). Conceptual frameworks for the integration of genetic and social epidemiology in complex diseases, Global Epidemiology, 8, 100156.